老化した組織や細胞では、不溶性タンパク質の増加が認められますが、これも蛋白質の翻訳後修飾の結果であると考えられています。

1. Lens proteomics: the accumulation of crystallin modifications in the mouse lens with age.
   Ueda Y, Duncan MK, David LL.
   Invest Ophthalmol Vis Sci 2002 Jan;43(1):205-15
   
   
2. Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice.
   Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, Moechars D, Van Leuven F.
   Exp Gerontol 2000 Sep;35(6-7):831-41
   
   
3. The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
   Wang J, Dickson DW, Trojanowski JQ, Lee VM.
   Exp Neurol 1999 Aug;158(2):328-37
   
   
4. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.
   Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG.
   J Neurosci 2001 Jan 15;21(2):372-81
   
   
5. Lens protein composition, glycation and high molecular weight aggregation in aging rats.
   Swamy MS, Abraham EC.
   Invest Ophthalmol Vis Sci 1987 Oct;28(10):1693-701
   
   
6. Characterization of water-insoluble proteins in human lens nuclei.
   amei A, Iwata S, Horwitz J.
   Jpn J Ophthalmol 1987;31(3):433-9
   
   
7. Effects of age and diabetes mellitus on the solubility and nonenzymatic glucosylation of human skin collagen.
   Schnider SL, Kohn RR.
   J Clin Invest 1981 Jun;67(6):1630-5
   
   

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