幾つかの酵素において、老化に伴う比活性の低下が報告されています。 　その原因については、色々な可能性が考えられますが、翻訳後の修飾や酸化変性によって生じた不活性な酵素が、分解除去されずに残るためではないかと考えられています。

1. Role of membrane lipids in regulation of vulnerability to oxidative stress in PC12 cells: implication for aging.
   Free Radic Biol Med 2001 Mar 15;30(6):671-8
   Denisova NA, Cantuti-Castelvetri I, Hassan WN, Paulson KE, Joseph JA.
   
   
2. Occurrence of GABA-transaminase in the thymus gland of juvenile and aged rats.
   Cavallotti C, Artico M, De Santis S.
   Eur J Histochem 1999;43(4):293-9
   
   
3. Age-related changes in tetrahydrobiopterin and GTP-cyclohydrolase activity in the brain and adrenal gland of rats.
   Hossain MA, Masserano JM, Weiner N.
   Neurobiol Aging 1995 Jul-Aug;16(4):627-32
   
   
4. Protein oxidation and proteolysis during aging and oxidative stress.
   Starke-Reed PE, Oliver CN.
   Arch Biochem Biophys 1989 Dec;275(2):559-67
   
   
5. Age-dependent alterations of DNA synthesis. Terminal deoxynucleotidyl transferase and DNA polymerase activities in bone marrow subpopulations from mice.
   Muller WE, Zahn RK, Geurtsen W, Munsch N.
   Mech Ageing Dev 1980 Jun;13(2):119-26
   
   

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