蛋白質の発現レベルの変化

　老化した動物の細胞や培養条件下で老化した細胞では、細胞内および細胞膜表面の蛋白質の発現レベルが変化している事が観察されています。
　このような『加齢に伴う蛋白質発現レベルの変化』は、『細胞における老化現象』の一つであり、この上流には『老化の根本原因』が潜んでいるものと思われます。またこの下流においては、細胞機能の低下に伴い臓器機能が不全を起こすリスクが高まってくることから、これらの現象は個体の老化を考える上でも極めて重要であると考えられます。
　蛋白質の発現レベルが変化する原因としては、(1)塩基置換やDNAメチル化などの遺伝子上の変化、(2)ヒストンや転写因子などの蛋白質の変化、(3)細胞外マトリクスなどの細胞周囲の微小環境の変化などが考えられますが、それらの変化の背景には酸素ラジカルなどによる酸化的なストレスの影響があるものと考えられます。


参考文献
  1. The effect of aging on constitutive mRNA levels and lipopolysaccharide inducibility of acute phase genes.
    Post DJ; Carter KC; Papaconstantinou J
    Ann N Y Acad Sci, 1991, 621:, 66-77
  2. Differential extracellular matrix gene expression by fibroblasts during their proliferative life span in vitro and at senescence.
    Choi AM; Olsen DR; Cook KG; Deamond SF; Uitto J; Bruce SA
    J Cell Physiol, 1992 Apr, 151:1, 147-55
  3. Changes in hepatic androgen sensitivity and gene expression during aging.
     Chatterjee B; Roy AK
    J Steroid Biochem Mol Biol, 1990 Nov, 37:3, 437-45
  4. Trophic regulation of basal forebrain gene expression in aging and Alzheimer's disease.
    Higgins GA; Koh S; Neve RL; Mufson EJ; Chen KS; Gage FH
    Prog Brain Res, 1990, 86:, 239-55
    (Abstract unavailable online.)
  5. Differential gene expression between young and senescent, quiescent WI-38 cells.
    Doggett DL; Rotenberg MO; Pignolo RJ; Phillips PD; Cristofalo VJ
    Mech Ageing Dev, 1992 Sep, 65:2-3, 239-55
  6. Aging abolishes the estradiol-induced suppression and diurnal rhythm of proopiomelanocortin gene expression in the arcuate nucleus.
     Weiland NG; Scarbrough K; Wise PM
    Endocrinology, 1992 Dec, 131:6, 2959-64
  7. Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110 alpha and WRN during fibroblast aging in vitro.
     Matuoka K; Takenawa T
    Biochim Biophys Acta, 1998 Feb, 1401:2, 211-5
  8. Isolation and identification of aging-related cDNAs in the mouse.
     Friedman V; Wagner J; Danner DB
    Mech Ageing Dev, 1990 Mar, 52:1, 27-43
  9. Metabolic mass, metabolic rate, caloric restriction, and aging in male Fischer 344 rats.
    Greenberg JA, Boozer CN
    Mech Ageing Dev 2000 Jan 24;113(1):37-48
  10. Calcium binding protein (calbindin-D28k) gene expression in the developing and aging mouse cerebellum.
     Iacopino AM; Rhoten WB; Christakos S
    Brain Res Mol Brain Res, 1990 Oct, 8:4, 283-90
  11. Age-related alterations of somatostatin gene expression in different rat brain areas.
     Florio T; Ventra C; Postiglione A; Schettini G
    Brain Res, 1991 Aug, 557:1-2, 64-8
  12. Age-dependent modifications of gene expression in human fibroblasts.
     Cristofalo VJ; Volker C; Francis MK; Tresini M
    Crit Rev Eukaryot Gene Expr, 1998, 8:1, 43-80
  13. Conformation and expression of the albumin gene of young and old rats.
     Singh A; Singh S; Kanungo MS
    Mol Biol Rep, 1990 Nov, 14:4, 251-4
  14. Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome.
     Beyreuther K; Pollwein P; Multhaup G; Mning U; Kig G; Dyrks T; Schubert W; Masters CL
    Ann N Y Acad Sci, 1993 Sep, 695:, 91-102
  15. Involvement of cytokine gene expression in the age-dependent decline of NK cell response.
     Hsueh CM; Chen SF; Ghanta VK; Hiramoto RN
    Cell Immunol, 1996 Nov, 173:2, 221-9
  16. On the role of intracellular physicochemistry in quantitative gene expression during aging and the effect of centrophenoxine. A review.
     Zs Nagy I
    Arch Gerontol Geriatr, 1989 Nov, 9:3, 215-29
  17. Expression of a human chimeric transferrin gene in senescent transgenic mice reflects the decrease of transferrin levels in aging humans.
     Adrian GS; Herbert DC; Robinson LK; Walter CA; Buchanan JM; Adrian EK; Weaker FJ; Eddy CA; Yang F; Bowman BH
    Biochim Biophys Acta, 1992 Sep, 1132:2, 168-76
  18. Proliferative and metabolic capacity of rat embryo fibroblasts immortalized by c-myc depends on cellular age at oncogenic transfection.
     Simm A; Halle JP; Adam G
    Eur J Cell Biol, 1994 Oct, 65:1, 121-31
  19. Influence of development and aging on brain biopterin: implications for dopa-responsive dystonia onset.
     Furukawa Y; Kish SJ
    Neurology, 1998 Aug, 51:2, 632-4
  20. Somatostatin gene expression in hypothalamus and cortex of aging male rats.
     Sonntag WE; Boyd RL; Booze RM
    Neurobiol Aging, 1990 Jul, 11:4, 409-16
  21. Tissue specific expression of mouse transferrin during development and aging.
     Yang FM; Friedrichs WE; Buchanan JM; Herbert DC; Weaker FJ; Brock JH; Bowman BH
    Mech Ageing Dev, 1990 Nov, 56:2, 187-97
  22. Alterations in the molecular response to DNA damage during cellular aging of cultured fibroblasts: reduced AP-1 activation and collagenase gene expression.
     Choi AM; Pignolo RJ; apRhys CM; Cristofalo VJ; Holbrook NJ
    J Cell Physiol, 1995 Jul, 164:1, 65-73
  23. Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives.
     Melcangi RC; Magnaghi V; Cavarretta I; Martini L; Piva F
    Neuroscience, 1998 Jul, 85:2, 569-78
  24. Cloning and identification of genes that associate with mammalian replicative senescence.
     Gonos ES; Derventzi A; Kveiborg M; Agiostratidou G; Kassem M; Clark BF; Jat PS; Rattan SI
    Exp Cell Res, 1998 Apr, 240:1, 66-74
  25. Retroviral gene expression as a possible biomarker of aging.
     Wada Y; Tsukada M; Kamiyama S; Koizumi A
    Int Arch Occup Environ Health, 1993, 65:1 Suppl, S235-9
  26. Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer.
     Iwase T; Tanaka M; Suzuki M; Naito Y; Sugimura H; Kino I
    Biochem Biophys Res Commun, 1993 Jul, 194:2, 698-705
  27. Enhanced ovarian inhibin subunit gene expression in aging rats is due to chronic anovulation.
     Jih MH; Lu JK; Wan YJ; Wu TC
    Biol Reprod, 1993 Dec, 49:6, 1208-14
  28. Caloric restriction increases the expression of heat shock protein in the gut.
     Ehrenfried JA; Evers BM; Chu KU; Townsend CM Jr; Thompson JC
    Ann Surg, 1996 May, 223:5, 592-7; discussion 597-9
  29. Elevated level of gas3 gene expression is correlated with G0 growth arrest in human fibroblasts.
     Karlsson C; Afrakhte M; Westermark B; Paulsson Y
    Cell Biol Int, 1999, 23:5, 351-8
  30. Nerve growth factor receptor gene expression in human peripheral blood lymphocytes in aging.
     Kittur SD; Song L; Endo H; Adler WH
    J Neurosci Res, 1992 Jul, 32:3, 444-8
  31. The decline of atrial natriuretic peptide (ANP) gene expression in older rats and the effects of ginsenoside on ANP gene expression.
     Hong M; Jin Y; Mai YQ; Boersma A; Han KK; Vantyghem MC; Lefebvre J
    Comp Biochem Physiol [B], 1992 Jan, 101:1-2, 35-9
  32. Aberrant gene expression and aging: examination of tissue-specific mRNAs in young and old rats.
     Sato AI; Schneider EL; Danner DB
    Mech Ageing Dev, 1990 May, 54:1, 1-12
  33. Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability.
     Uz T; Pesold C; Longone P; Manev H
    FASEB J, 1998 Apr, 12:6, 439-49
  34. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein.
     Matsumura Y; Aizawa H; Shiraki Iida T; Nagai R; Kuro o M; Nabeshima Y
    Biochem Biophys Res Commun, 1998 Jan, 242:3, 626-30
  35. Aging-related changes in IGF-II and c-fos gene expression in the rat brain.
     Kitraki E; Bozas E; Philippidis H; Stylianopoulou F
    Int J Dev Neurosci, 1993 Feb, 11:1, 1-9
  36. A developmentally regulated DNA-binding protein from mouse brain stimulates myelin basic protein gene expression.
     Haas S; Gordon J; Khalili K
    Mol Cell Biol, 1993 May, 13:5, 3103-12
  37. Age-related decrease in proopiomelanocortin gene expression in the arcuate nucleus of the male rat brain.
     Gruenewald DA; Matsumoto AM
    Neurobiol Aging, 1991 Mar, 12:2, 113-21
  38. Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence.
     Horikawa I; Oshimura M; Barrett JC
    Mol Carcinog, 1998 Jun, 22:2, 65-72
  39. A developmentally regulated DNA-binding protein from mouse brain stimulates myelin basic protein gene expression.
     Haas S; Gordon J; Khalili K
    Mol Cell Biol, 1993 May, 13:5, 3103-12
  40. Identification of a rat brain gene associated with aging by PCR differential display method.
     Wu HC; Lee EH
    J Mol Neurosci, 1997 Feb, 8:1, 13-8
  41. Aging and photoaging affect gene expression in cultured human keratinocytes.
     Gilchrest BA; Garmyn M; Yaar M
    Arch Dermatol, 1994 Jan, 130:1, 82-6
  42. Effects of ginsenoside Rg1 on c-fos gene expression and cAMP levels in rat hippocampus.
     Liu M; Zhang JT
    Chung Kuo Yao Li Hsueh Pao, 1996 Mar, 17:2, 171-4
  43. Extracellular matrix modifications in rat tissues of different ages. Correlations between elastin and collagen type I mRNA expression and lysyl-oxidase activity.
     Quaglino D; Fornieri C; Nanney LB; Davidson JM
    Matrix, 1993 Nov, 13:6, 481-90
  44. Gene expression of high- (p140trk) and low-affinity nerve growth factor receptor (LNGFR) in the adult and aged human peripheral nervous system.
     Yamamoto M; Sobue G; Mutoh T; Li M; Doyu M; Mitsuma T; Kimata K
    Neurosci Lett, 1993 Aug, 158:1, 39-43
  45. Genetic instability and aging: theories, facts, and future perspectives.
     Slagboom PE; Vijg J
    Genome, 1989, 31:1, 373-85
  46. Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts.
     Imai S; Fujino T; Nishibayashi S; Manabe T; Takano T
    Mol Cell Biol, 1994 Nov, 14:11, 7182-94
  47. Forced expression of hic-5, a senescence-related gene, potentiates a differentiation process of RCT-1 cells induced by retinoic acid.
     Shibanuma M; Nose K
    Int J Biochem Cell Biol, 1998 Jan, 30:1, 39-45
  48. TGF-beta 1 gene expression in cultured human keratinocytes does not decrease with biologic age.
     Compton C; Tong T; Trookman N; Zhao H; Roy D
    J Invest Dermatol, 1994 Jul, 103:1, 127-33
  49. Age-dependent expression of protein kinase C isoforms in rat islets.
     Fletcher DJ; Ways DK
    Diabetes, 1991 Nov, 40:11, 1496-503
  50. Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes.
     ONeill L; Holbrook NJ; Fargnoli J; Lakatta EG
    Cardioscience, 1991 Mar, 2:1, 1-5
  51. Effect of aging on gastrin receptor gene expression in rat stomach.
     Waki S; Kinoshita Y; Wang HY; Asahara M; Matsushima Y; Hassan MS; Okada A; Maekawa T; Fukui H; Kawanami C; Kishi K; Chiba T
    Peptides, 1998, 19:2, 225-9
  52. Gene expression and aging.
     Thakur MK; Oka T; Natori Y
    Mech Ageing Dev, 1993 Jan, 66:3, 283-98
  53. Effect of age and apoptosis on the mouse homologue of the huWRN gene.
     Wu J; He J; Mountz JD
    Mech Ageing Dev, 1998 Jun, 103:1, 27-44
  54. Age-dependent increase in neuropeptide Y gene expression in rat adrenal gland and specific brain areas.
     Higuchi H; Yokokawa K; Iwasa A; Yoshida H; Miki N
    J Neurochem, 1991 Dec, 57:6, 1840-7
  55. Age-related decrease of growth hormone and prolactin gene expression in the mouse pituitary.
     Crew MD; Spindler SR; Walford RL; Koizumi A
    Endocrinology, 1987 Oct, 121:4, 1251-5
  56. Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity.
     Vallejo AN; Nestel AR; Schirmer M; Weyand CM; Goronzy JJ
    J Biol Chem, 1998 Apr, 273:14, 8119-29
  57. Axonal atrophy in aging is associated with a decline in neurofilament gene expression.
     Parhad IM; Scott JN; Cellars LA; Bains JS; Krekoski CA; Clark AW
    J Neurosci Res, 1995 Jun, 41:3, 355-66
  58. Replicative senescence and differentiated gene expression in cultured adrenocortical cells.
     Hornsby PJ; Ryan RF; Cheng CY
    Exp Gerontol, 1989, 24:5-6, 539-58
  59. Stepwise transformation of astrocytes by simian virus 40 large T antigen and epidermal growth factor receptor overexpression.
     Frisa PS; Walter EI; Ling L; Kung HJ; Jacobberger JW
    Cell Growth Differ, 1996 Feb, 7:2, 223-33
  60. Modulation of gene expression during aging of human vascular endothelial cells.
     Kumazaki T
    Hiroshima J Med Sci, 1993 Jun, 42:2, 97-100
  61. Biological significance of DNA methylation in the ageing process.
     Ono T; Uehara Y; Kurishita A; Tawa R; Sakurai H
    Age Ageing, 1993 Jan, 22:1, S34-43
  62. Immunoglobulin VH gene expression in human aging.
     Wang X; Stollar BD
    Clin Immunol, 1999 Nov, 93:2, 132-42
  63. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases.
     Iacopino AM; Christakos S
    Proc Natl Acad Sci U S A, 1990 Jun, 87:11, 4078-82
  64. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart.
     Fuentes JJ; Pritchard MA; Planas AM; Bosch A; Ferrer I; Estivill X
    Hum Mol Genet, 1995 Oct, 4:10, 1935-44
  65. Loss of collagenase gene expression in immortalized clones of SV40 T antigen-transformed human diploid fibroblasts.
     Imai S; Takano T
    Biochem Biophys Res Commun, 1992 Nov, 189:1, 148-53
  66. Enhanced expression of myogenic regulatory genes in aging skeletal muscle.
     Musar A; Cusella De Angelis MG; Germani A; Ciccarelli C; Molinaro M; Zani BM
    Exp Cell Res, 1995 Nov, 221:1, 241-8
  67. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts.
     Saretzki G; Feng J; von Zglinicki T; Villeponteau B
    J Gerontol A Biol Sci Med Sci, 1998 Nov, 53:6, B438-42
  68. Molecular events involved in transcriptional activation of heat shock genes become progressively refractory to heat stimulation during aging of human diploid fibroblasts.
     Liu AY; Choi HS; Lee YK; Chen KY
    J Cell Physiol, 1991 Dec, 149:3, 560-6
  69. Stability of DNA methylation of X-chromosome genes during aging [see comments]
     Pagani F; Toniolo D; Vergani C
    Somat Cell Mol Genet, 1990 Jan, 16:1, 79-84
  70. Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression.
     Tang Z; Zhang Z; Zheng Y; Corbley MJ; Tong T
    Mech Ageing Dev, 1994 Jan, 73:1, 57-67
  71. Genetic control of telomerase and replicative senescence in human and rodent cells.
     Newbold RF
    Ciba Found Symp, 1997, 211:, 177-89; discussion 189-97
  72. Retroviral gene expression as a possible biomarker of aging.
     Wada Y; Tsukada M; Kamiyama S; Koizumi A
    Int Arch Occup Environ Health, 1993, 65:1 Suppl, S235-9
  73. Modulation of gene expression during aging of human vascular endothelial cells.
     Kumazaki T
    Hiroshima J Med Sci, 1993 Jun, 42:2, 97-100
  74. Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats.
     Sutin EL; Dement WC; Heller HC; Kilduff TS
    Neurobiol Aging, 1993 Sep, 14:5, 441-6
  75. Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.
     Bond JA; Blaydes JP; Rowson J; Haughton MF; Smith JR; Wynford Thomas D; Wyllie FS
    Cancer Res, 1995 Jun, 55:11, 2404-9
  76. A novel regulatory element associated with age-dependent expression of the rat androgen receptor gene.
     Supakar PC; Song CS; Jung MH; Slomczynska MA; Kim JM; Vellanoweth RL; Chatterjee B; Roy AK
    J Biol Chem, 1993 Dec, 268:35, 26400-8
  77. Age-related changes in expression of the neural cell adhesion molecule in skeletal muscle: a comparative study of newborn, adult and aged rats.
     Andersson AM; Olsen M; Zhernosekov D; Gaardsvoll H; Krog L; Linnemann D; Bock E
    Biochem J, 1993 Mar, 290 ( Pt 3):, 641-8
  78. Attenuated expression of 70-kDa heat shock protein in WI-38 human fibroblasts during aging in vitro.
     Bonelli MA; Alfieri RR; Petronini PG; Brigotti M; Campanini C; Borghetti AF
    Exp Cell Res, 1999 Oct, 252:1, 20-32
  79. Slow changes of tyrosine hydroxylase gene expression in dopaminergic brain neurons after neurotoxin lesioning: a model for neuron aging.
     Pasinetti GM; Osterburg HH; Kelly AB; Kohama S; Morgan DG; Reinhard JF Jr; Stellwagen RH; Finch CE
    Brain Res Mol Brain Res, 1992 Mar, 13:1-2, 63-73
  80. Effect of age on cutaneous interleukin 1 expression.
     Sauder DN; Ponnappan U; Cinader B
    Immunol Lett, 1989 Jan, 20:2, 111-4
  81. Protein L-isoaspartyl methyltransferase: developmentally regulated gene expression and protein localization in the central nervous system of aged rat.
     Shirasawa T; Endoh R; Zeng YX; Sakamoto K; Mori H
    Neurosci Lett, 1995 Mar, 188:1, 37-40
  82. Effect of high-glucose concentrations on the expression of collagens and fibronectin by fibroblasts in culture.
     Benazzoug Y; Borchiellini C; Labat Robert J; Robert L; Kern P
    Exp Gerontol, 1998 Aug, 33:5, 445-55
  83. UVA irradiation stimulates the synthesis of various matrix-metalloproteinases (MMPs) in cultured human fibroblasts.
     Herrmann G; Wlaschek M; Lange TS; Prenzel K; Goerz G; Scharffetter Kochanek K
    Exp Dermatol, 1993 Mar, 2:2, 92-7
  84. Metallothionein expression and stress responses in aging human diploid fibroblasts.
     Luce MC; Schyberg JP; Bunn CL
    Exp Gerontol, 1993 Jan, 28:1, 17-38
  85. Fibronectin and collagen gene expression during in vitro ageing of pig skin fibroblasts.
     Martin M; el Nabout R; Lafuma C; Crechet F; Remy J
    Exp Cell Res, 1990 Nov, 191:1, 8-13
  86. The senescence marker protein (SMP-2) of the rat liver: purification, immunochemical characterization and age-dependent regulation.
     Chatterjee B; Mancini MA; Roy AK
    Biochim Biophys Acta, 1990 May, 1034:2, 162-9
  87. Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid.
     Swisshelm K; Ryan K; Tsuchiya K; Sager R
    Proc Natl Acad Sci U S A, 1995 May, 92:10, 4472-6
  88. Decreased NGFI-A gene expression in the hippocampus of cognitively impaired aged rats.
     Yau JL; Olsson T; Morris RG; Noble J; Seckl JR
    Brain Res Mol Brain Res, 1996 Dec, 42:2, 354-7
  89. Decreased tyrosine hydroxylase mRNA but not cholecystokinin mRNA in the pars compacta of the substantia nigra and ventral tegmental area of aged rats.
     Schuligoi R; Fernandez J; Heavens RP; Sirinathsinghji DJ
    Brain Res Mol Brain Res, 1993 Sep, 19:4, 333-8
  90. Short-term caloric restriction augments age-related decreases in gastrin content and release.
     Chu KU; Evers BM; Ishizuka J; Beauchamp RD; Greeley GH Jr; Townsend CM Jr; Thompson JC
    Mech Ageing Dev, 1996 May, 87:1, 25-33
  91. Microarray analysis of replicative senescence.
     Shelton DN; Chang E; Whittier PS; Choi D; Funk WD
    Curr Biol, 1999 Sep, 9:17, 939-45
  92. Anomalous expression of microtubule-associated protein 1B in the hippocampus and cortex of aged rats treated with pentylenetetrazole.
     Popa Wagner A; Fischer B; Platt D; Neubig R; Schmoll H; Kessler C
    Neuroscience, 1999, 94:2, 395-403
  93. Altered expression and regulation of the alpha 5beta1 integrin-fibronectin receptor lead to reduced amounts of functional alpha5beta1 heterodimer on the plasma membrane of senescent human diploid fibroblasts.
     Hu Q; Moerman EJ; Goldstein S
    Exp Cell Res, 1996 May, 224:2, 251-63
  94. Metalloproteinase and TIMP-1 gene expression during replicative senescence.
    Millis AJ; McCue HM; Kumar S; Baglioni C
    Exp Gerontol, 1992 Jul, 27:4, 425-8
    (Abstract unavailable online.)
  95. Galanin receptors in the hippocampus and entorhinal cortex of aged Fischer 344 male rats.
     Planas B; Kolb PE; Raskind MA; Miller MA
    Neurobiol Aging, 1998 Sep, 19:5, 427-35
  96. Altered gene expression during cellular aging.
     Smith JR; Pereira Smith OM
    Genome, 1989, 31:1, 386-9
  97. Down syndrome and the trisomy 16 mouse: impact of gene imbalance on brain development and aging.
    Coyle JT; Oster Granite ML; Reeves R; Hohmann C; Corsi P; Gearhart J
    Res Publ Assoc Res Nerv Ment Dis, 1991, 69:, 85-99
    (Abstract unavailable online.)
  98. Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats.
     Herman JP; Chen KC; Booze R; Landfield PW
    Neurobiol Aging, 1998 Nov, 19:6, 581-7
  99. Aging-specific expression of Drosophila hsp22.
     King V; Tower J
    Dev Biol, 1999 Mar, 207:1, 107-18
  100. Nuclear factor kappa B functions as a negative regulator for the rat androgen receptor gene and NF-kappa B activity increases during the age-dependent desensitization of the liver.
     Supakar PC; Jung MH; Song CS; Chatterjee B; Roy AK
    J Biol Chem, 1995 Jan, 270:2, 837-42
  101. Expression of the growth arrest specific genes in rat embryonic fibroblasts undergoing senescence.
     Gonos ES
    Ann N Y Acad Sci, 1998 Jun, 851:, 466-9
  102. Basal and induced amounts of interleukin-6 mRNA decline progressively with age in human fibroblasts.
     Goodman L; Stein GH
    J Biol Chem, 1994 Jul, 269:30, 19250-5
  103. Age-dependent expression of cytochrome P-450s in rat liver.
     Imaoka S; Fujita S; Funae Y
    Biochim Biophys Acta, 1991 Oct, 1097:3, 187-92
  104. Age-related changes in the mRNA expression of actin isoforms in Drosophila melanogaster.
     Labuhn M; Brack C
    Gerontology, 1997, 43:5, 261-7
  105. Age-related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL-associated serine esterase genes and the perforin gene in mice.
     Bloom ET; Umehara H; Bleackley RC; Okumura K; Mostowski H; Babbitt JT
    Eur J Immunol, 1990 Oct, 20:10, 2309-16
  106. Blunting of the neurotensin mRNA response to haloperidol in the striatum of aging rats: possible relationship to decline in dopamine D2 receptor expression.
     Dobie DJ; Merchant KM; Hamblin MW; Vatassery GT; Dysken MW; Dorsa DM
    Brain Res, 1993 Jul, 616:1-2, 105-13




　老化研究基盤情報の目次に戻る