Aging-related proteins
Categories	Protein Name	Relation	Methods		Authors	Journals
[A]
1) simple protein	serum albumin		the Longitudinal Aging Study Amsterdam		Schalk BW et al	Aging Clin Exp Res. 2005
	IgG&beta2-microglobulin	kynurenic acid			Kepplinger B et al	Neurosignals. 2005
	immunoglobulins (Ig)				Bouras C et al	Brain Res Brain Res Rev. 2005
	caveolae				Wheaton K et al	J Cell Physiol. 2001
	Caveolin-1	in determining the senescent phenotype			Cho KA et al	Mech Ageing Dev. 2005
	Caveolin-1	regulating focal adhesion kinase activity			Cho KA et al	J Biol Chem. 2004
	Caveolin-1				Cho KA et al	J Biol Chem. 2003
	Caveolin-1				Volonte D et al	Mol Biol Cell. 2002
	caveolin-1 alpha and -3	cardiac aging	immunohistolabelling and Western blot		Ratajczak P et.al	Cardiovasc Res. 2003
	caveolin		Electron microscopic analysis		Park WY et al	J Biol Chem. 2000
	H1(o) histone	deamidation			Lindner H et al	J Cancer Res Clin Oncol. 1999
	histones: H2A:H2B and H3:H4	transglutaminase (tTGase)			Kim JH et al	Ann N Y Acad Sci. 2001
	Histone variants of H2A and H3in vitro aging				Rogakou EP and Sekeri-Pataryas KE	Exp Gerontol. 1999
	histone H4	acetylation			Kozurkova M	Mech Ageing Dev. 1995
	histone H4	trimethylation of histone H4	mass spectrometric analysis, liquid chromatographic method		Sarg B	J Biol Chem. 2002
2) conjugated protein
2-1) glycoprotein	GAP-43（growth-associated protein）				Schmoll H et al	Gerontology. 2005
	GAP-43（growth-associated protein）		Western blot analysis,immunohistochemistry		Casoli T et al	Mech Ageing Dev. 2001
	GAP-43（growth-associated protein）				Casoli T et al	Brain Res. 1996
	SCG10 (neuronal growth-associated proteins)				Mori N and Morii H	J Neurosci Res. 2002
	ICAM-1(intercellular adhesion molecule-1)				Gorgoulis VG et al	Lab Invest. 2005
	ICAM-1(intercellular adhesion molecule-1)				Kletsas D et al	Ann N Y Acad Sci. 2004
	ICAM-1(intercellular adhesion molecule-1)				Forsey RJ et al	Mech Ageing Dev. 2003
	GFAP (glial fibrillary acidic protein )	Alzheimer's disease.	two-dimensional immunoblotting		Korolainen MA et al	Neurobiol Dis. 2005
	GFAP (glial fibrillary acidic protein )		aging		Rozovsky I et al	Neurobiol Aging. 2005
	GFAP (glial fibrillary acidic protein )		Two-dimensional electrophoresis,Western blots,　 immunocytochemistry		Porchet R et al	Proteomics. 2003
	GFAP (glial fibrillary acidic protein )		Immunohistochemistry, Western blot, RTPCR		Wu Y et al	Neurochem Int. 2005
	SMP30 (senescence marker protein-30)				Maruyama N et al	Ann N Y Acad Sci. 2004
	SMP30 (senescence marker protein-30)				Ishigami A et al	Am J Pathol. 2002
	SMP30 (senescence marker protein-30)				Fujita T et al	Mech Ageing Dev. 1999
	Heat shock proteins (Hsp27, Hsp60, Hsp72 and Hsc70)				Colotti C et al	Biogerontology. 2005
	Hsp 70				Gutsmann-Conrad A et al	Exp Cell Res. 1998
	Hsp 70 serum		ELISA		Njemini R et al	Biogerontology. 2004
	Hsp 60 & Hsp 70 serum				Rea IM et al	Exp Gerontol. 2001
	Hsp 70				Starnes JW et al	J Gerontol A Biol Sci Med Sci. 2005
	Hsp 32				Njemini R et al	J Clin Immunol. 2005
	32 kDa heat shock protein (HSP)				Hirose W et al	Leg Med (Tokyo). 2003
	Hsp27	in human monocytes and lymphocytes			Njemini R et al	Exp Gerontol. 2006
	clusterin				Shapiro LA et al	Brain Res. 2004
	clusterin				Ishikawa T et al	Leg Med (Tokyo). 2005
	clusterin				Strocchi P et al	Neurobiol Aging. 2006
	cytokines (TNF-alpha and IL-6)				Bruunsgaard H and Pedersen BK	Immunol Allergy Clin North Am. 2003
	cytokine (IL-1 beta,TNF-alpha,IL-6)				Roubenoff R et al	J Gerontol A Biol Sci Med Sci. 1998
	IL-4 (cytokine)	long term potentiation (LTP)			Maher FO et al	Neurobiol Aging. 2005
	IL-4 (cytokine)	long term potentiation (LTP)			Nolan Y et al	J Biol Chem. 2005
	Clusterin/apolipoprotein J				Petropoulou C et al	FEBS Lett. 2001
	Clusterin/apolipoprotein J		In situ hybridization and immunohistochemical techniques		Morgan TE et al	Neuroscience. 1999
	P-glycoprotein				Vogelgesang S et al	Curr Alzheimer Res. 2004
	P-glycoprotein				Aggarwal S et al	J Clin Immunol. 1997
	P-glycoprotein				Vogelgesang S et al	Pharmacogenetics. 2002
	ERRP (EGF-receptor related protein)				Majumdar AP et al	Dig Dis Sci. 2003
	ERRP (EGF-receptor related protein)				Schmelz EM et al	Mech Ageing Dev. 2004
	ERRP (EGF-receptor related protein)				Majumdar AP	J Physiol Pharmacol. 2003
2-2) lipoprotein	Apolipoprotein E (apo E)				Nanetti L et al	Brain Res. 2005
	Apolipoprotein E (apo E)				Gee JR et al	Exp Gerontol. 2005
	Apolipoprotein E (apo E)		immunohistochemistry		Hilmer SN et al	Exp Gerontol. 2004
	Apolipoprotein B(apo B)				Malek G et al	Am J Pathol. 2003
	Apolipoprotein B(apo B)				Gardner CD et al	Prev Med. 2000
	Apolipoprotein B(apo B)				Matthan NR et al	Arterioscler Thromb Vasc Biol. 2005
	Apolipoprotein A-I				Nakamura T et al	J Lipid Res. 1999
2-3) hemeprotein	Neuroglobin (Ngb)		Western blot		Sun Y et al	Neurobiol Aging. 2005
	catalase				Schriner SE et al	Science. 2005
	catalase				Brown-Borg HM and Rakoczy SG	Exp Gerontol. 2000
	catalase				Shin MH et al	J Invest Dermatol. 2005
	catalase				Cutler RG	Rejuvenation Res. 2005
	peroxidase				Rodrigues Siqueira I et al	Life Sci. 2005
	cytochrome c		northern blot analysis, in situ hybridization, and immunofluorescence analyses		Manczak M et al	J Neurochem. 2005
	cytochrome　 oxidase		morphometric methods		Bertoni-Freddari C et al	Ann N Y Acad Sci. 2004
	cytochrome c oxidase				Xin MG et al	Mech Ageing Dev. 2003
	cytochrome c oxidase				Maurer I et al	Neurobiol Aging. 2000
	cytochrome c oxidase	Alzheimer's disease			Ojaimi J et al	Ann Neurol. 1999
	cytochrome c oxidase	? Alzheimer's disease			Kish SJ et al	J Neurochem. 1999
2-3) metalloprotein	ferritin	Alzheimer's disease			Quintana C et al	J Struct Biol. 2006
	ferritin				Hirose W et al	Leg Med (Tokyo). 2003
	ferritin	substantia nigra			Zecca L et al	J Neurochem. 2001
	ferritin	neurodegenerative diseases(AD and PD)			Bartzokis G et al	Ann N Y Acad Sci. 2004
	ferritin	Alzheimer's disease			Dobson J	Cell Mol Biol (Noisy-le-grand). 2001
	ferritin				Focht SJ et al	Neuroscience. 1997
2-4) flavoprotein.	electron-transfer flavoprotein		MS/MS analysis		Kanski J et al	Am J Physiol Heart Circ Physiol. 2005
2-5) phosphoprotein	phospho-tau proteins				Niewiadomska G et al	Ann N Y Acad Sci. 2005
	tau	neurofibrillary tau inclusions			Ishihara T et al	Am J Pathol. 2001
	Tau 1	Basal forebrain			Niewiadomska G and Baksalerska-Pazera M.	Neuroreport. 2003
	phosphorylated tau (p-tau)	Apolipoprotein E (apoE)in AD			Brecht WJ et al	J Neurosci. 2004
	tau isoforms				Bahr BA and Vicente JS.	J Neuropathol Exp Neurol. 1998
	tau phosphorylation	Insulin-like growth factor (IGF) action			Cheng CM et al	Endocrinology. 2005
	tau		autopsy records		Yang W et al	Brain Res Dev Brain Res. 2005
	tau phosphorylation	the hippocampal CA3 region			Hartig W et al	Brain Res. 2005
	tau phosphorylation				Head E et al	Neurobiol Aging. 2005
	tau phosphorylation	human ApoE4 in neurons			Tesseur I et al	Am J Pathol. 2000
	tau phosphorylation	senescence-accelerated mouse (SAM).			Canudas AM et al	Mech Ageing Dev. 2005
[B]
aging
	PSD (postsynaptic density) proteins)	in spatial learning			Nyffeler M et al	Neurobiol Aging. 2005
	PSD				Nicholson DA et al	J Neurosci. 2004
	synaptic proteins	rat brain			Shimohama S et al	Biochem Biophys Res Commun. 1998
	Nogo-A(Myelin-associated protein)	Alzheimer disease			Gil V et al	J Neuropathol Exp Neurol. 2006
	p63				Keyes WM and Mills AA	Cell Cycle. 2006
	p63				Keyes WM et al	Genes Dev. 2005
	p53		Flow cytometric analysis		Wesierska-Gadek J et al	J Physiol Pharmacol. 2005
	p53				Bauer JH	Curr Biol. 2005
	p53				Vaziri H et al	EMBO J. 1997
	p53				Donehower LA	J Cell Physiol. 2002
	p53	oxidative stress-induced senescence			Favetta LA et al	Exp Cell Res. 2004
	p53 and p21(Waf1).				Yeo EJ et al	Exp Gerontol. 2000
	p21(Waf1/Cip1)	DNA methylation			Zheng QH et al	J Cell Biochem. 2006
	p21(waf1/Cip1)				Chen X et al	Cell Res. 2002
	p21(WAF1/CIP1)		Western blot analysis, immunohistochemistry		Ding G et al	Exp Mol Pathol. 2001
	p21	p21-E2F interaction			Afshari CA et al	Cell Growth Differ. 1996
	cyclin-dependent kinase inhibitors (p21 and p16)				Stein GH et al	Mol Cell Biol. 1999
	connective tissue growth factor (CTGF)		Proteome analysis		Kim KH et al	Biochem Biophys Res Commun. 2004
	calcium binding proteins (CBP)(Calbindin-D(28k) (CB), calretinin (CRT))				Bu J et al	Exp Neurol. 2003
	calcium binding protein (calbindin-D28K)				Geula C et al	J Neuropathol Exp Neurol. 2003
	Calbindin protein	senescence-accelerated mice			Armbrecht HJ et al	Brain Res. 1999
	calbindin-D-9k protein (calbindin)				Armbrecht HJ et al	Arch Biochem Biophys. 2003
	calbindin-D28K				Geula C et al	J Neuropathol Exp Neurol. 2003
	proteasome (20S proteasome and 26S proteasom)				Ding Q et al	Antioxid Redox Signal. 2006
	alpha1-antichymotrypsin (ACT)	serum inflammatory protein			Dik MG et al	Neurology. 2005
	APP (amyloid precursor protein)				Kern A et al	J Biol Chem. 2006
	p66(Shc) protein				Migliaccio E et al	Antioxid Redox Signal. 2006
	p66(Shc) protein				Favetta LA et al	Exp Cell Res. 2004
	ECTO-NOX protein				Morre DJ and Morre DM	Rejuvenation Res. 2006
	ECTO-NOX protein				Morre DM et al	Mol Cell Biochem. 2003
	ECTO-NOX protein				Morre DJ and Morre DM	Biofactors. 2003
		type V intermediate filament proteins			Mattout A et al	Curr Opin Cell Biol. 2006
	Lamin A	Hutchinson-Gilford progeria (HGPS)			Scaffidi P and Misteli T	Science. 2006
	CREB1 protein(cAMP-response-element-binding protein )				Brightwell JJ et al	Neurobiol Learn Mem. 2004
	CBP(cAMP-response-element-binding protein (CREB) binding protein )				Chung YH et al	Brain Res. 2002
age-related renal disease	Sterol regulatory element binding proteins (SREBP)				Jiang T et al	J Am Soc Nephrol. 2005
	Sterol regulatory element binding proteins (SREBP)				Jiang T et al	Kidney Int. 2005

*This bibliographic database is prepared by Dr. Hirota in TMIG Proteomics Collaboration Center.